Javad Behravan

Visiting Scholar
School of Pharmacy
University of Watesrloo

Education:

  • Pharm.D. Mashhad University of medical Sciences, Mashhad, Iran

  • Ph.D. The University of Sheffield, Sheffield, UK

About:

Javad is currently working on the development and characterization of tunable superlytic Lambda phage constructs expressing specific Her2 derived peptides intended for antitumor immunity induction in a murine Tubo model of breast cancer.

 A selection of his recent publications on breast cancer research is as follows:

Nourbakhsh, M., Jaafari, MR, Lage, H., Abnous, K., Mosaffa, F., Badiee, A. and Behravan, J. (2015). Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer. IJBMS (in press).

Kalalinia, F., Elahian, F., Mosaffa, F., and Behravan, J. (2014). Celecoxib up regulates the expression of drug efflux transporter ABCG2 in breast cancer cell lines. I. J. Pharmaceut. Research.  13 (4): 1391-1399

Kalalinia, F., Elahian, F., Hassani, M., Kasaeean, J. and Behravan, J. (2012). Phorbol Ester TPA Modulates Chemoresistance in the Drug Sensitive Breast Cancer Cell Line MCF-7 by Inducing Expression of Drug Efflux Transporter ABCG2. Asian Pacific J. Cancer Prevent. 13, 2979-2984.

Malekshah, OM., lage, H., Bahrami,  AR., Tavakol Afshari, J., Behravan, J. (2012). PXR and NF-KB correlate with the inducing effects of IL-1ß and TNF-a on ABCG2 expression in breast cancer cell lines. European Journal of Pharmaceutical Sciences. 47 474–480.

Mosaffa, F., Kalalinia, F., and Behravan, J (2012). Pro-inflammatory Cytokines Interleukin-1 beta, Interleukin 6 and Tumor Necrosis Factor-alpha Alter the Expression and Function of ABCG2 in Cervix and Gastric Cancer Cells. Molecular and cellular biochemistry . 363(1-2):385-93.

Kalalinia, F., Mosaffa, F., and Behravan, J. (2011). MCF-7 Breast Cancer Cell Line, a Model for the Study of the Association Between Inflammation and ABCG2-Mediated Multi Drug Resistance. In: Gunduz, M., and Gunduz, S., (Ed.), Focusing Tumor Microenvironment, Stem cells and Metastasis, Intech Publishers. 343-358.